With two-out, in the third Samardzija (8-12, 4.44 ERA) gave up a single and back-to-back walks to load the bases before striking out Xavier Paul to end the inning.
Devin Mesoraco hit a solo home run to left field in the fourth inning to push the Reds lead to 3-0.Hannahan’s three-run pinch hit home run in the sixth inning doubled the Reds lead.
Samardzija allowed eight hits and six runs, struck out five and walked three in 5 2/3 innings. Leake also went 5 2/3 innings, gave up four hits and zero runs, struck out six and walked four.
Cubs left-hander Chris Rusin (2-3, 2.89 ERA) and Pittsburgh Pirates left-hander Jeff Locke (9-5, 3.23 ERA) are the starters for the four-game series opener in Pittsburgh on Thursday night at 6:05 p.m. CT (WGN/WGN 720).